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KMID : 0356019930080010021
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Koean Jounral of Critical Care Medicine
1993 Volume.8 No. 1 p.21 ~ p.26
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Clinical Effects of Doxazosin in the Treatment of Essential Hypertension
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김경수
김정현/임헌길/이방헌/이정균
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Abstract
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Doxazosin is a new selective a1-adrenergic blocking agent resembling prazosin. The antihypertensive efficacy and safety of doxazosin were assessed in 20 essential hypertensive patients.
The results of a -12 weeks trial in hypertensive patents demonstrated significant reduction in systolic blood pressure and diastolic pressure.
The mean dose of therapeutic effecacy was 4.0mg/day. The adverse effects noted with doxazosin administration were dizziness, vertigo, weakness and fatigue. There were no significant laboratory changes in the completion of the clinical study.
The changes in the serum lipid profiles of patients with doxazosin were a decrease in total cholesterol and slight increase in HDL-cholesterol.
Doxazosin has been evaluated alone for the treatment of mild to moderate hypertension.
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